What’s New in Research
Rebecca Amariglio, PhD, of the Center for Alzheimer Research and Treatment in BWH’s Department of Neurology and BWH’s Ann Romney Center for Neurologic Diseases, and colleagues have found that self-reported concerns about cognitive decline and memory loss are associated with early biomarker evidence of Alzheimer’s disease (AD) pathology.
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Exploring how Lenalidomide Combats Cancer
Benjamin Ebert, MD, PhD, a hematologist and oncologist for the Department of Medicine at the Brigham, and his colleagues have looked at the mechanism of action of lenalidomide, a derivative of the 1950s morning sickness drug that caused birth malformations called thalidomide. It is effective in treating myelodysplastic syndrome (MDS).
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Plaque on Attack and a Surprising Finding
Guo-Ping Shi, ScD, a biochemist in BWH’s Cardiovascular Division, and his team have explored whether the absence of the receptor for interleukin 18 (IL18), an inflammatory cell signaling protein, affects the hardening of the arteries. The team has also uncovered surprising evidence about IL18’s interactions.
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Francisco Quintana, PhD, of the Ann Romney Center for Neurologic Diseases, and colleagues have identified metabolic pathways that regulate a population of T cells that help control immune responses and play a role in autoimmune diseases such as multiple sclerosis.
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